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China
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Xian, Shaanxi
Salvia miltiorrhiza, also known as red sage, Chinese sage, tan shen, or danshen, is a perennial plant in the genus Salvia, highly valued for its roots in traditional Chinese medicine.Dihydrotanshinone, tanshinone I, and tanshinone IIA are also under study for anti-cancer effects.Tanshinone IIA is one of the most abundant constituents of the root of Salvia miltiorrhiza which exerts antioxidant and anti-inflammatory actions in many experimental disease models in laboratory animals,Tanshinone IIA (Tan IIA) has been widely used for various cardiovascular and cerebrovascular disorders in Asian countries. Tanshinone IIA might be a novel promising therapeutic agent for oxidative stress injury in neurodegenerative diseases. Tanshinone IIA may improve renal dysfunction associated with chronic kidney disease. Tan IIA was effective for attenuating the extent of brain edema formation in response to ischemia injury in rats.Tanshinone IIA has been identified as a natural monoacylglycerol lipase (MAGL) inhibitor with an IC*0 value of *8 nM. This has potential for the treatment of cardiovascular diseases and may be a good candidate for the treatment of Alzheimer's disease or other MAGL-associated diseases.
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