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AZD9291

FOB Price

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10 Gram Minimum Order

Country:

China

Model No:

-

FOB Price:

Get Latest Price

Place of Origin:

China

Price for Minimum Order:

-

Minimum Order Quantity:

10 Gram

Packaging Detail:

Packed in food-grade plastic bag inside and aluminum-foil bag outside

Delivery Time:

15 days for ready

Supplying Ability:

1 Kilogram per Month

Payment Type:

T/T, L/C, Western Union, Money Gram, PayPal

Product Group :

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Free Member

Contact Person QA

No.125 kangtian Road, Changsha, Hunan

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Product Specification

  • Other Names: 2-​Propenamide, N-​[2-​[[2-​(dimethylamino)​ethyl]​methylamino]​-​4-​methoxy-​5-​[[4-​(1-​methyl-​1H
  • Type: Pharmaceutical Intermediates
  • Purity (%): 99
  • Brand Name: Flying Bird
  • Application: Pharmaceutical Intermediates
  • Appearance: yellow solid

Product Description

生物活性
AZD***1 是口服不可逆的,选择性的突变体EGFR抑制剂,其对外显子*9缺失的 EGFR, L**8R/T**0M EGFR,和 WT EGFR的IC*0分别为*2.*2, *1.*4 和**3.8 nM。
体外研究
与体外野生型相比,在突变EGFR 细胞系中AZD***1能更有效的抑制增殖。
体内研究
AZD***1(5mg / kg p.o.)引起整个EGFRm+(PC9)和EGFRm+/ T**0M(H***5)肿瘤模型肿瘤中显著的肿瘤消退,伴随着对体内EGFR磷酸化和下游关键信号通路,如AKT和ERK的显著抑制。
特征
Orally bioavailable mutant-selective EGFR inhibitor that has been tested in Phase III clinical trials for treatment of Non-Small Cell Lung Cancer.

Country: China
Model No: -
FOB Price: Get Latest Price
Place of Origin: China
Price for Minimum Order: -
Minimum Order Quantity: 10 Gram
Packaging Detail: Packed in food-grade plastic bag inside and aluminum-foil bag outside
Delivery Time: 15 days for ready
Supplying Ability: 1 Kilogram per Month
Payment Type: T/T, L/C, Western Union, Money Gram, PayPal
Product Group : intermediate

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QA < Changsha Flying Bird Biological Technolo >

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